Examples of Client Studies

Boomana M, Forster I, Vederas J, Groman D, Jones S. Soybean meal-induced enteritis in Atlantic salmon (Salmo salar) and Chinook salmon (Oncorhynchus tshawytscha) but not in pink salmon (O. gorbuscha). Aquaculture. 2018; 483: 238-243.

This study compared intestinal pathology and the microbiome of different salmon fed a diet comprising 20% soybean meal; researchers found that mucosal enteritis varied among salmon species but the diet had no influence on microbiome diversity or composition.

Dimitriu PA, Iker B, Malik K, Leung H, Mohn WW, Hillebrand, GG. New insights into the intrinsic and extrinsic factors that shape the human skin microbiome. mBio. 2019.

This epidemiological study was the largest human skin microbiome survey ever published; it included 495 individuals between the ages of 9 and 78, with over 2500 skin swab samples from four skin sites and the mouth. Between 12 and 20 percent of the bacterial microbiome variability was explained by demographic, physiologic, and lifestyle factors. Also, specific taxa on the skin were associated with chronological age.

Nielsen G, Hatam I, Abuan K, et al. Semi-passive in-situ pilot scale bioreactor successfully removed sulfate and metals from mine impacted water under subarctic climatic conditions. Water Res. 2018; 140: 268-279.

Researchers in this study tested whether sulfate reducing bacteria in subarctic mine environments can be enriched with a carbon source to remove sulfate and metals in a semi passive pilot scale bioreactor. Molasses was added to anaerobic bioreactors to mimic in situ conditions and microbial analysis confirmed the sulfate reducing bacteria were enriched and the population remained stable over 14 months. Removal efficiency of Zn and Cd varied from 20.9% in winter to 89.3% in summer and 39% in winter to 90.5% in summer, respectively.’

Patankar J, Wong C, Morampudi V, et al. Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition. Am J Physiol Endocrinol Metab. 2018; 314: E418-E432.

This study found, in Cyp8b1-/- mice, that altered bile acid composition maintains metabolic and respiratory function by repressing hepatic de novo lipogenesis and driving beneficial changes in gut microbiota.

Subedi G, Taylor J, Hatam I, Baldwin S. Simultaneous selenate reduction and denitrification by a consortium of enriched mine site bacteria. Chemosphere. 2017; 183: 536-545.

In this study, researchers report on an enrichment of a bacterial assemblage capable of denitrification and selenate reduction in natural marsh sediment impacted by a mine. Genomic analysis of the bacteria uncovered open reading frames homologous to selenate reductase subunits. The results indicate that native mine site bacteria may be used to remove selenate and nitrate from wastewater.

Tremblay S, Côté N, Grenier G, et al. Ileal antimicrobial peptide expression is dysregulated in old age. Immun Ageing. 2017; 14: 19.

In this study, which aimed to uncover the mechanisms underlying geriatric gastrointestinal dysfunction, researchers found changes in antimicrobial peptide gene expression as well as histological damage of the ileal epithelium and slight differences in gut microbiota composition in aged mice.

Vonaesch P, Morien E, Andrianonimiadana L, et al. Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa. PNAS. 2018; 115(36): E8489-E8498.

Vonaesch P, Randremanana R, Gody J-C, et al. Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project. BMC Pediatrics. 2018; 18: 236.

Brett Finlay – Co-Founder and Scientific Advisor

Our co-founding scientists and our technical team are active contributors to the scientific literature on the microbiome. Below, we highlight some of the most important recent publications.

Arrieta MC, Arévalo A, Stiemsma L, et al. Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting. J Allergy Clin Immunol. 2018.

Cait A, Hughes M, Antignano F, et al. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunol. 2018; 11: 785-795.

Costea P, Zeller G, Sunagawa S, et al. Towards standards for human fecal sample processing in metagenomic studies. Nat Biotechnol. 2017; 35: 1069-1076.

Arrieta M, Stiemsma L, Dimitriu P, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med. 2015; 7: 307ra152.

Brown E, Wlodarska M, Willing B, et al. Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model. Nat Commun. 2015; 6: 7806.

Search PubMed for current results.

Bill Mohn – Co-Founder and Scientific Advisor

Cardenas E, Orellana L, Konstantinidis K, Mohn W. Effects of timber harvesting on the genetic potential for carbon and nitrogen cycling in five North American forest ecozones. Sci Rep. 2018; 8: 3142.

Holert J, Cardenas E, Bergstrand L, et al. Metagenomes reveal global distribution of bacterial steroid catabolism in natural, engineered and host environments. mBio. 2018; 9: e02345-17.

Cait A, Hughes M, Antignano F, et al. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunol. 2018; 11: 785-795.

Wilhelm RC, Singh R, Eltis LD, Mohn WW. Bacterial contributions to delignification and lignocellulose degradation in forest soils with metagenomic and quantitative stable isotope probing. ISME J. 2018 (in press).

Cait A, Cardenas E, Dimitriu P, Amenyogbe N, Dai D, Cait J, Sbihi H, Stiemsma L, Subbarao P, Mandhane PJ, Becker AB, Moraes TJ, Sears MR, Lefebvre DL, Azad MB, Kollmann T, Turvey SE, Mohn WW. Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization. J Allergy Clin Immunol. 2019.

Search PubMed for current results