Examples of Microbiome Insights’ Client Studies

Soybean meal-induced enteritis in Atlantic salmon (Salmo salar) and Chinook salmon (Oncorhynchus tshawytscha) but not in pink salmon (O. gorbuscha). Marije Boomana, Ian Forster, John C.Vederas, David B.Groman, Simon R.M.Jones.

This study compared intestinal pathology and the microbiome of different salmon fed a diet comprising 20% soybean meal; researchers found that mucosal enteritis varied among salmon species but the diet had no influence on microbiome diversity or composition.

Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition. Patankar JV, Wong CK, Morampudi V, Gibson WT, Vallance B, Ioannou GN, Hayden M. Am J Physiol Endocrinol Metab. 2017 Oct 24:ajpendo.00172.2017. doi: 10.1152/ajpendo.00172.2017. PMID: 29066462

This study found, in Cyp8b1-/- mice, that altered bile acid composition maintains metabolic and respiratory function by repressing hepatic de novo lipogenesis and driving beneficial changes in gut microbiota.

Ileal antimicrobial peptide expression is dysregulated in old age. Tremblay S, Côté NML, Grenier G, Duclos-Lasnier G, Fortier LC, Ilangumaran S, Menendez A. Immun Ageing. 2017 Aug 29; 14:19. doi: 10.1186/s12979-017-0101-8.

In this study, which aimed to uncover the mechanisms underlying geriatric gastrointestinal dysfunction, researchers found changes in antimicrobial peptide gene expression as well as histological damage of the ileal epithelium and slight differences in gut microbiota composition in aged mice.

Brett Finlay – Co-Founder and Scientific Advisor

Our co-founding scientists and our technical team are active contributors to the scientific literature on the microbiome. Below, we highlight some of the most important recent publications.

Click on “Search PubMed” for the most current search results in each category.

Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Cait A, Hughes MR, Antignano F, Cait J, Dimitriu PA, Maas KR, Reynolds LA, Hacker L, Mohr J, Finlay BB, Zaph C, McNagny KM, Mohn WW. Mucosal Immunol. 2017 Oct 25. doi: 10.1038/mi.2017.75. PMID: 29067994

Towards standards for human fecal sample processing in metagenomic studies. Costea PI, Zeller G, Sunagawa S, Pelletier E, Alberti A, Levenez F, Tramontano M, Driessen M, Hercog R, Jung FE, Kultima JR, Hayward MR, Coelho LP, Allen-Vercoe E, Bertrand L, Blaut M, Brown JRM, Carton T, Cools-Portier S, Daigneault M, Derrien M, Druesne A, de Vos WM, Finlay BB, Flint HJ, Guarner F, Hattori M, Heilig H, Luna RA, van Hylckama Vlieg J, Junick J, Klymiuk I, Langella P, Le Chatelier E, Mai V, Manichanh C, Martin JC, Mery C, Morita H, O’Toole PW, Orvain C, Patil KR, Penders J, Persson S, Pons N, Popova M, Salonen A, Saulnier D, Scott KP, Singh B, Slezak K, Veiga P, Versalovic J, Zhao L, Zoetendal EG, Ehrlich SD, Dore J, Bork P. Nat Biotechnol. 2017 Nov;35(11):1069-1076. doi: 10.1038/nbt.3960. PMID: 28967887

Early infancy microbial and metabolic alterations affect risk of childhood asthma. Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, Kuzeljevic B, Gold MJ, Britton HM, Lefebvre DL, Subbarao P, Mandhane P, Becker A, McNagny KM, Sears MR, Kollmann T; CHILD Study Investigators, Mohn WW, Turvey SE, Finlay BB. Sci Transl Med. 2015 Sep 30;7(307):307ra152. doi: 10.1126/scitranslmed.aab2271. PMID: 26424567

Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model. Brown EM, Wlodarska M, Willing BP, Vonaesch P, Han J, Reynolds LA, Arrieta MC, Uhrig M, Scholz R, Partida O, Borchers CH, Sansonetti PJ, Finlay BB. Nat Commun. 2015 Aug 4;6:7806. doi: 10.1038/ncomms8806. PMID: 26241678

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Bill Mohn – Co-Founder and Scientific Advisor

Effects of timber harvesting on the genetic potential for carbon and nitrogen cycling in five North American forest ecozones. Cardenas E, Orellana LH, Konstantinidis KT, Mohn WW. 2018. Scientific Reports, advance on line, doi:10.1038/s41598-018-21197-0

Metagenomes reveal global distribution of bacterial steroid catabolism in natural, engineered and host environments. Holert J, Cardenas E, Bergstrand L, Zaikova E, Hahn A, Hallam SJ, Mohn WW. 2018. mBio 9:e02345-17

Microbiome-driven allergic lung inflammation is ameliorated by short chain fatty acids. Cait A, Hughes MR, Antignano F, Cait J, Dimitriu PA, Maas KR, Reynolds LA, Hacker L, Mohr J, Finlay BB, Zaph C, McNagny KM, Mohn WW. 2017. Mucosal Immunology, advance on line doi: 10.1038/mi.2017.75

Biogeography and Organic Matter Removal Shape Long-term Effects of Timber Harvesting on Forest Soil Microbial Communities. Wilhelm RC, Cardenas E, Maas K, Leung H, McNeil L, Berch S, Chapman W, Hope G, Kranabetter JM, Dube S, Busse M, Fleming R, Hazlett P, Webster KL, Morris D, Scott DA, Mohn WW. 2017. ISME J. 11:2552-2568

The Host Response to the Lung Microbiota in Chronic Obstructive Pulmonary Disease. Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, Hogg JC. 2015.American Journal of Respiratory and Critical Care Medicine, 192(4):438-445

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