Examples of Microbiome Insights’ Client Studies

Boomana M, Forster I, Vederas J, Groman D, Jones S. Soybean meal-induced enteritis in Atlantic salmon (Salmo salar) and Chinook salmon (Oncorhynchus tshawytscha) but not in pink salmon (O. gorbuscha). Aquaculture. 2018; 483: 238-243.

This study compared intestinal pathology and the microbiome of different salmon fed a diet comprising 20% soybean meal; researchers found that mucosal enteritis varied among salmon species but the diet had no influence on microbiome diversity or composition.

Patankar J, Wong C, Morampudi V, et al. Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition. Am J Physiol Endocrinol Metab. 2018; 314: E418-E432.

This study found, in Cyp8b1-/- mice, that altered bile acid composition maintains metabolic and respiratory function by repressing hepatic de novo lipogenesis and driving beneficial changes in gut microbiota.

Tremblay S, Côté N, Grenier G, et al. Ileal antimicrobial peptide expression is dysregulated in old age. Immun Ageing. 2017; 14: 19.

In this study, which aimed to uncover the mechanisms underlying geriatric gastrointestinal dysfunction, researchers found changes in antimicrobial peptide gene expression as well as histological damage of the ileal epithelium and slight differences in gut microbiota composition in aged mice.

Subedi G, Taylor J, Hatam I, Baldwin S. Simultaneous selenate reduction and denitrification by a consortium of enriched mine site bacteria. Chemosphere. 2017; 183: 536-545.

In this study, researchers report on an enrichment of a bacterial assemblage capable of denitrification and selenate reduction in natural marsh sediment impacted by a mine. Genomic analysis of the bacteria uncovered open reading frames homologous to selenate reductase subunits. The results indicate that native mine site bacteria may be used to remove selenate and nitrate from wastewater.

Nielsen G, Hatam I, Abuan K, et al. Semi-passive in-situ pilot scale bioreactor successfully removed sulfate and metals from mine impacted water under subarctic climatic conditions. Water Res. 2018; 140: 268-279.

Researchers in this study tested whether sulfate reducing bacteria in subarctic mine environments can be enriched with a carbon source to remove sulfate and metals in a semi passive pilot scale bioreactor. Molasses was added to anaerobic bioreactors to mimic in situ conditions and microbial analysis confirmed the sulfate reducing bacteria were enriched and the population remained stable over 14 months. Removal efficiency of Zn and Cd varied from 20.9% in winter to 89.3% in summer and 39% in winter to 90.5% in summer, respectively.

Brett Finlay – Co-Founder and Scientific Advisor

Our co-founding scientists and our technical team are active contributors to the scientific literature on the microbiome. Below, we highlight some of the most important recent publications.

Cait A, Hughes M, Antignano F, et al. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunol. 2018; 11: 785-795.

Costea P, Zeller G, Sunagawa S, et al. Towards standards for human fecal sample processing in metagenomic studies. Nat Biotechnol. 2017; 35: 1069-1076.

Arrieta M, Stiemsma L, Dimitriu P, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci Transl Med. 2015; 7: 307ra152.

Brown E, Wlodarska M, Willing B, et al. Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model. Nat Commun. 2015; 6: 7806.

Search PubMed for current results.

Bill Mohn – Co-Founder and Scientific Advisor

Cardenas E, Orellana L, Konstantinidis K, Mohn W. Effects of timber harvesting on the genetic potential for carbon and nitrogen cycling in five North American forest ecozones. Sci Rep. 2018; 8: 3142.

Holert J, Cardenas E, Bergstrand L, et al. Metagenomes reveal global distribution of bacterial steroid catabolism in natural, engineered and host environments. mBio. 2018; 9: e02345-17.

Cait A, Hughes M, Antignano F, et al. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunol. 2018; 11: 785-795.

Wilhelm R, Cardenas E, Maas K, et al. Biogeography and organic matter removal shape long-term effects of timber harvesting on forest soil microbial communities. ISME J. 2017; 11: 2552-2568.

Sze M, Dimitriu P, Suzuki M, et al. The host response to the lung microbiota in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015; 192: 438-445.

Search PubMed for current results